Stephen O'Rahilly Selected Research

1-Acylglycerol-3-Phosphate O-Acyltransferase (1 Acylglycerol 3 Phosphate O Acyltransferase)

3/2015	Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis.
10/2003	Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy.

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Stephen O'Rahilly Research Topics

Disease

68	Obesity 01/2022 - 04/2002
41	Insulin Resistance 01/2021 - 03/2002
23	Type 2 Diabetes Mellitus (MODY) 01/2021 - 03/2002
22	Body Weight (Weight, Body) 01/2021 - 05/2004
19	Lipodystrophy 01/2021 - 04/2003
15	Morbid Obesity 01/2020 - 08/2002
11	Weight Loss (Weight Reduction) 12/2021 - 07/2002
9	Hyperphagia (Overeating) 10/2014 - 08/2006
8	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2017 - 04/2003
8	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2016 - 10/2003
6	Hyperinsulinism (Hyperinsulinemia) 10/2020 - 10/2002
6	Adrenal Insufficiency (Adrenal Gland Hypofunction) 11/2018 - 08/2002
6	Dyslipidemias (Dyslipidemia) 10/2016 - 11/2004
6	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 03/2015 - 10/2003
5	Weight Gain 01/2022 - 12/2009
5	Coronary Disease (Coronary Heart Disease) 12/2018 - 08/2005
5	Fatty Liver 01/2017 - 02/2009
5	Overweight 10/2010 - 02/2008
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 06/2011
3	Cachexia 10/2022 - 06/2013
3	Coronary Artery Disease (Coronary Atherosclerosis) 12/2017 - 06/2011
3	Neoplasms (Cancer) 01/2016 - 06/2012
3	Dwarfism 10/2015 - 03/2011
3	Hypertension (High Blood Pressure) 07/2007 - 04/2003
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 10/2002
2	Renal Insufficiency (Renal Failure) 12/2021 - 01/2016
2	Hyperandrogenism 01/2021 - 01/2007
2	Nausea 01/2020 - 01/2018
2	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 01/2020 - 12/2017
2	Vomiting 01/2020 - 01/2018
2	Anorexia 01/2020 - 05/2006
2	Familial Partial Lipodystrophy (Dunnigan Syndrome) 10/2017 - 03/2007
2	Hypertriglyceridemia 01/2017 - 02/2009
2	Hypoglycemia (Reactive Hypoglycemia) 01/2017 - 11/2003
2	Non-alcoholic Fatty Liver Disease 08/2012 - 04/2003
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2008 - 12/2006
2	Hypersensitivity (Allergy) 07/2007 - 05/2004
2	Hyperlipidemias (Hyperlipidemia) 10/2004 - 10/2002
1	Cockayne Syndrome (Syndrome, Cockayne) 12/2021

Drug/Important Bio-Agent (IBA)

32	Insulin (Novolin)FDA Link 01/2022 - 03/2002
21	LeptinIBA 01/2020 - 06/2002
20	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2020 - 08/2002
15	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 07/2002
15	Proteins (Proteins, Gene)FDA Link 10/2015 - 08/2002
13	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 01/2021 - 03/2003
11	PPAR gammaIBA 12/2006 - 03/2002
8	Triglycerides (Triacylglycerol)IBA 01/2022 - 11/2008
8	AdiponectinIBA 12/2017 - 04/2003
7	LipidsIBA 10/2020 - 03/2006
7	MelanocortinsIBA 01/2020 - 08/2002
7	Peptides (Polypeptides)IBA 12/2019 - 12/2006
6	HDL CholesterolIBA 01/2022 - 11/2004
5	Insulin ReceptorIBA 10/2016 - 05/2004
5	Protein Isoforms (Isoforms)IBA 10/2015 - 04/2002
5	LigandsIBA 10/2008 - 01/2003
4	Biological ProductsIBA 01/2022 - 05/2003
4	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 01/2020
4	Hormones (Hormone)IBA 01/2020 - 09/2007
4	Pharmaceutical PreparationsIBA 01/2020 - 07/2005
4	Nonsense Codon (Nonsense Mutation)IBA 12/2017 - 09/2003
4	Leptin ReceptorsIBA 12/2014 - 01/2007
3	Growth Differentiation Factor 15IBA 10/2022 - 01/2020
3	GlucocorticoidsIBA 01/2020 - 08/2005
3	Rosiglitazone (Avandia)FDA Link 01/2018 - 11/2004
3	2,4-thiazolidinedione (thiazolidinedione)IBA 01/2018 - 04/2003
3	DNA (Deoxyribonucleic Acid)IBA 09/2014 - 10/2006
3	Proprotein Convertase 1IBA 09/2013 - 11/2003
3	CorticosteroneIBA 05/2011 - 08/2006
3	Messenger RNA (mRNA)IBA 01/2010 - 07/2002
3	EnzymesIBA 09/2007 - 11/2003
2	CarbohydratesIBA 01/2022 - 08/2002
2	Appetite Depressants (Anorectics)IBA 12/2021 - 12/2019
2	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2021 - 10/2003
2	LDL CholesterolIBA 10/2018 - 10/2016
2	oxidized low density lipoproteinIBA 10/2018 - 10/2016
2	Transcription Factors (Transcription Factor)IBA 11/2017 - 12/2009
2	setmelanotideIBA 10/2017 - 01/2016
2	Nonesterified Fatty Acids (NEFA)IBA 01/2017 - 04/2003
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2017 - 01/2015
2	Phosphotransferases (Kinase)IBA 01/2017 - 10/2016
2	Amino Acids FDA Link 11/2016 - 02/2013
2	Leucine (L-Leucine)FDA Link 11/2016 - 04/2003
2	ProinsulinIBA 01/2016 - 07/2007
2	1-Acylglycerol-3-Phosphate O-Acyltransferase (1 Acylglycerol 3 Phosphate O Acyltransferase)IBA 03/2015 - 10/2003
2	lipineIBA 01/2012 - 09/2008
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 10/2010 - 01/2009
2	Neurokinin BIBA 10/2009 - 03/2009
2	AntibodiesIBA 02/2009 - 06/2007
2	ElementsIBA 02/2009 - 03/2004
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 02/2008 - 04/2003
2	GlycogenIBA 01/2008 - 01/2006
2	Adrenocorticotropic Hormone (ACTH)FDA Link 08/2006 - 10/2004
2	Tamoxifen FDA LinkGeneric 05/2006 - 07/2005
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2004 - 10/2003
1	HDL LipoproteinsIBA 01/2022
1	Formaldehyde (Formol)FDA Link 12/2021
1	Glucagon-Like Peptide-1 ReceptorIBA 01/2021

Therapy/Procedure

16	Therapeutics 01/2021 - 04/2002
2	Injections 01/2021 - 10/2004
1	Drug Therapy (Chemotherapy) 12/2021